Resources
SubstanceNucleicAcid

Properties

NameRequiredTypeDescription
sequenceTypeNoCodeableConceptThe type of the sequence shall be specified based on a controlled vocabulary
numberOfSubunitsNointegerThe number of linear sequences of nucleotides linked through phosphodiester bonds shall be described. Subunits would be strands of nucleic acids that are tightly associated typically through Watson-Crick base pairing. NOTE: If not specified in the reference source, the assumption is that there is 1 subunit
areaOfHybridisationNostringThe area of hybridisation shall be described if applicable for double stranded RNA or DNA. The number associated with the subunit followed by the number associated to the residue shall be specified in increasing order. The underscore “” shall be used as separator as follows: “Subunitnumber Residue”
oligoNucleotideTypeNoCodeableConcept(TBC)
subunitNoSubstanceNucleicAcidSubunitSubunits are listed in order of decreasing length; sequences of the same length will be ordered by molecular weight; subunits that have identical sequences will be repeated multiple times
- idNostringUnique id for inter-element referencing
- extensionNoExtension[]Additional content defined by implementations
- modifierExtensionNoExtension[]Extensions that cannot be ignored even if unrecognized
- subunitNointegerIndex of linear sequences of nucleic acids in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts
- sequenceNostringActual nucleotide sequence notation from 5’ to 3’ end using standard single letter codes. In addition to the base sequence, sugar and type of phosphate or non-phosphate linkage should also be captured
- lengthNointegerThe length of the sequence shall be captured
- sequenceAttachmentNoAttachment(TBC)
- fivePrimeNoCodeableConceptThe nucleotide present at the 5’ terminal shall be specified based on a controlled vocabulary. Since the sequence is represented from the 5’ to the 3’ end, the 5’ prime nucleotide is the letter at the first position in the sequence. A separate representation would be redundant
- threePrimeNoCodeableConceptThe nucleotide present at the 3’ terminal shall be specified based on a controlled vocabulary. Since the sequence is represented from the 5’ to the 3’ end, the 5’ prime nucleotide is the letter at the last position in the sequence. A separate representation would be redundant
- linkageNoSubstanceNucleicAcidSubunitLinkageThe linkages between sugar residues will also be captured
- idNostringUnique id for inter-element referencing
- extensionNoExtension[]Additional content defined by implementations
- modifierExtensionNoExtension[]Extensions that cannot be ignored even if unrecognized
- connectivityNostringThe entity that links the sugar residues together should also be captured for nearly all naturally occurring nucleic acid the linkage is a phosphate group. For many synthetic oligonucleotides phosphorothioate linkages are often seen. Linkage connectivity is assumed to be 3’-5’. If the linkage is either 3’-3’ or 5’-5’ this should be specified
- identifierNoIdentifierEach linkage will be registered as a fragment and have an ID
- nameNostringEach linkage will be registered as a fragment and have at least one name. A single name shall be assigned to each linkage
- residueSiteNostringResidues shall be captured as described in 5.3.6.8.3
- sugarNoSubstanceNucleicAcidSubunitSugar5.3.6.8.1 Sugar ID (Mandatory)
- idNostringUnique id for inter-element referencing
- extensionNoExtension[]Additional content defined by implementations
- modifierExtensionNoExtension[]Extensions that cannot be ignored even if unrecognized
- identifierNoIdentifierThe Substance ID of the sugar or sugar-like component that make up the nucleotide
- nameNostringThe name of the sugar or sugar-like component that make up the nucleotide
- residueSiteNostringThe residues that contain a given sugar will be captured. The order of given residues will be captured in the 5‘-3‘direction consistent with the base sequences listed above

Search Parameters

None

Inherited Properties

NameRequiredTypeDescription
idNostringLogical id of this artifact
metaNoMetaMetadata about the resource
implicitRulesNouriA set of rules under which this content was created
languageNocodeLanguage of the resource content
textNoNarrativeText summary of the resource, for human interpretation
containedNoResource[]Contained, inline Resources
extensionNoExtension[]Additional content defined by implementations
modifierExtensionNoExtension[]Extensions that cannot be ignored

To view the FHIR specification for this resource, see SubstanceNucleicAcid.